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Posts Tagged ‘Zetia’

2-Azetidinones (Cholesterol absorption inhibitors)

May 14th, 2009

2-Azetidinones (Cholesterol absorption inhibitors) are used to reduce cholesterol levels.  Ezetimibe is the only 2-Azetidinone on the market.

Ezetimibe is a cholesterol lowering medication that acts by decreasing cholesterol absorption in the small intestine. Ezetimibe binds to the Niemann-Pick C1-Like 1 (NPC1L1) protein on intestinal epithelial cells and hepatocytes, preventing the absorption of dietary cholesterol.  This leads to lower serum cholesterol levels.

Because Ezetimibe works in a way very different than statins. Combining ezetimibe and a statin can result in even lower cholesterol levels than each drug could acheive if taken alone.

Medication Name Generic Available Discount Programs
Ezetimibe (Zetia, Vytorin*) No Patent expires in 2014

*Also contains simvastatin

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