2-Azetidinones (Cholesterol absorption inhibitors)
May 14th, 2009
2-Azetidinones (Cholesterol absorption inhibitors) are used to reduce cholesterol levels. Ezetimibe is the only 2-Azetidinone on the market.
Ezetimibe is a cholesterol lowering medication that acts by decreasing cholesterol absorption in the small intestine. Ezetimibe binds to the Niemann-Pick C1-Like 1 (NPC1L1) protein on intestinal epithelial cells and hepatocytes, preventing the absorption of dietary cholesterol. This leads to lower serum cholesterol levels.
Because Ezetimibe works in a way very different than statins. Combining ezetimibe and a statin can result in even lower cholesterol levels than each drug could acheive if taken alone.
| Medication Name | Generic Available | Discount Programs |
| Ezetimibe (Zetia, Vytorin*) | No | Patent expires in 2014 |
*Also contains simvastatin