Beta Blockers are used to treat hypertension, heart failure, and heart rhythm disturbances. Beta blockers have been shown to be effective at reducing the risk of heart attack and reduces the risk of death in patients with heart failure.
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ACE-Is (Angiotensin Converting Enzyme Inhibitors) are used to treat hypertension and congestive heart failure. ACE-Is have been shown to reduce the risk of death in patients with CHF.
*Also contains hydrochlorothiazide
** Also contains verapamil
*** Also contains felodipine
**** Also contains amlodipine
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Thiazolidinediones are used to treat diabetes type 2.
Thiazolidinediones (TZDs) bind to the PPAR gamma (peroxisome proliferator-activated receptors gamma) receptor. When the PPAR gamma is bound by a TZD, transcription of several genes is activated. PPAR Gamma activation leads to decreased insulin resistance, modified adipocyte differentiation, decreased leptin levels, and angiogenesis is inhibited.
Recent studies indicate that Thiazolidinedione use may increase the risk of heart failure and myocardial infarction.
*Includes metformin
**Includes
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Angiotensin II receptor blockers (ARBs) inhibit the renin-angiotensin-aldosterone system at the level of the Angiotensin II AT1-receptor. ARBs are used to treat high blood pressure, diabetic nephropathy, and congestive heart failure.
No generic ARBs are approved at this time.
In 2010, the patents for Eprosartan, Irbesartan, and Losartan will expire.
*Also contains hydrochlorothiazide
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