Statins (HMG-CoA Reductase Inhibitors)
May 13th, 2009
HMG-CoA reductase inhibitors (Statins) are a class of drugs that lower cholesterol levels by inhibiting cholesterol synthesis in the liver and other tissues. Statins also increase the production of low-density lipoprotein (LDL) receptors, causing lower serum LDL levels.
Statins are effective at lowering LDL cholesterol levels by as much as 60%.
Statins also reduce the risk of heart attack and stroke.
Statins are well-tolerated, but have two rare but significant side effects: liver and muscle injury.
Three statins are available in generic form.
| Medication Name | Generic Available | Discount Programs |
| Atorvastatin (Lipitor) | No | The Lipitor patent expires in 2011 |
| Fluvastatin (Lescol) | No | The Lescol patent expires in 2012 |
| Lovastatin (Mevacor) | Yes | Walmart | Target | Kroger |
| Pravastatin (Pravachol) | Yes | Walmart | Target |
| Rosuvastatin (Crestor) | No | The Crestor patent expires in 2016 |
| Simvastatin (Zocor) | Yes | KMart |
